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Unlike stable chemical compounds, peptides are vulnerable to heat, light, and pH changes

While existing animal models, which replicate specific phenotypes by targeting individual organ systems, offer the closest approximation to the HFpEF pathology, they still fall short of fully recapitulating the human condition

Indeed, non-lytic eryptosis is considered one mechanism that ensures the elimination of erythrocytes prior to the occurrence of premature hemolysis [89, 230,231,232]

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Spence JR, Lauf R, Shroyer NF (2011) Vertebrate intestinal endoderm development