Individuals with minimal weight to lose (BMI under 27 kg/m without comorbidities) do not meet clinical criteria for pharmacological weight loss treatment
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Who Is the Ideal Candidate for Semaglutide
Studies have shown that people tend to lose more weight on tirzepatide than other GLP-1s, likely because of the dual action.* *Tirzepatide as Compared with Semaglutide for the Treatment of Obesity, New England Journal of Medicine, July 2025
previous weight-loss treatments
Oral semaglutide can be used as a treatment intensification option even in addition to insulin.[] PIONEER 5 was a randomized, double-blind, placebo-controlled, parallel-group, multicentre, multinational trial that included 324 subjects with T2DM and estimated glomerular filtration rate (eGFR) 3059 mL/min/1.73 m 2 , on stable doses of 12 oral antidiabetic drugs (OADs) (metformin, SU) and/or basal insulin for 90 days randomized to oral semaglutide 14 mg and placebo (1:1)
