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Despite the limitations of the single-blind design in this clinical study, the advantages in exenatide-treated group in both cognitive and motor functions persisted in the follow-up study after a 12-mo wash-out period. 99 This suggests disease-modifying effects of exenatide, and the results are encouraging enough that a subsequent double-blind clinical study (NCT01971242) was initiated by the same investigators using a sustained release formulation of exenatide ( Bydureon : 2 mg administered subcutaneously once weekly) to evaluate in a similar group of PD subjects over a similar duration of time
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The "LR3" in IGF-1 LR3 refers to a specific modification in the protein structure, where an arginine (Arg) is substituted at the third position
governments and assess how trustworthy they might be
Risk-of-bias assessment was done independently by two reviewers and any disagreements were resolved through consensus
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