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It was showed that NP4 treatment leaded to an increase in pro-inflammatory M1-type macrophages and a decrease in anti-inflammatory M2-type macrophages in mouse tumor tissues, with the proportion of M1 to M2 macrophages being 4.4 times higher compared to untreated mouse tumor tissues (Fig

However, aside from the caffeine, the other ingredients are listed in a proprietary blend without precise dosing information, so both drinks only earn 3 out of 5 for the formulation