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METase was originally used to treat cancer in 1973 by Kreis et al., who found that METase isolated from Clostridium sporogenes inhibited the growth of Walker 256 carcinosarcoma in rats [35]

The brainstem-cortex network plays a critical role in the migraine pathway, with conditions such as insomnia, obstructive sleep apnea, sleep-related movement disorders, and REM sleep disturbances closely associated with migraine onset (Vgontzas and Pavlovi, 2018)

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PMID: 30852840

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High-dose strategy for intensive whitening therapy or severe medical cases requiring higher glutathione levels