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doi: 10.1016/j.yjmcc.2015.12.026

The semaglutide was further diluted in a saline solution and a physiological saline solution was used as vehicle control

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Both reach the brain via the area postrema, activating POMC neurons and suppressing NPY/AgRP orexigenic signaling

Kraft, M., Kraft, K., Grtner, S., Mayerle, J., Simon, P., Weber, E., Schtte, K., Stieler, J., Koula-Jenik, H., Holzhauer, P., Grber, U., Engel, G., Mller, C., Feng, Y.-S., Aghdassi, A., Nitsche, C., Malfertheiner, P., Patrzyk, M., Kohlmann, T., & Lerch, M

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