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However, it was unclear whether body mass changes were due to the release of -MSH or other substances also derived from proopiomelanocortin polypeptide (POMC)

Any molecular or cellular observations reported vary with the experimental model, peptide concentration, exposure time and methodological conditions

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The SURMOUNT-4 discontinuation data The SURMOUNT-4 trial specifically studied what happens when you stop tirzepatide after successful weight loss

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And we got to the right answer