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Sitagliptin demonstrates selectivity for DPP-4 and does not inhibit DPP-8 or DPP-9 activity in vitro at concentrations approximating those from therapeutic doses

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No significant differences were observed with respect to the percentage of lung lesions when the entire study population of cohort 2 was analyzed

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However, as compared with l-carnitine group, d-carnitine feeding reduced the acyl-carnitine concentration from 10 822 to 5482 ng/g, and increased lipid deposition from 1197 to 2021 % and the mRNA expression of the genes involved in -oxidation and detoxification in the liver