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One study showed that leucine-rich repeat kinase 2 (LRRK2) participates in the regulation of FAO, and its deficiency might promote inflammation in a palmitic acid-induced NAFLD mouse model

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Loss of function mutations in either Apo B-100 or MTTP result in the failure to produce VLDL and marked decreases in plasma triglyceride and cholesterol levels (familial hypobetalipoproteinemia or abetalipoproteinemia) (56)