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The decrease in MACE did not reach statistical significance for the group which gained weight, as so few of those on semaglutide (0.5%) gained weight so the sample size was small

Ozempic is FDA-approved to treat Type 2 diabetes, and Wegovy is FDA-approved for weight loss

Tirzepatide, in particular, has shown superior results in reducing A1c compared to semaglutide in head-to-head trials

3.4 Evaluation of Semaglutide Exposures and Bioavailability Following Oral Administration in Subjects with T2D With or Without Upper GI Disease The re-estimated model based on data from the trial in 55 subjects with T2D with or without upper GI disease [21] included covariate factors for T2D and for upper GI disease

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