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The calculated activation energies (G in kcal mol -1 ) for the abstraction the C2 proton of 7 to produce the cyanidin enolate ( 8-enolate) were found to be almost identical for the wild-type and the C13S variant, in agreement with their similar dehydratase activity measured experimentally

10.1007/s40005-022-00610-x 99 EscudierB.DorvalT.ChaputN.AndrF.CabyM.-P.NovaultS.et al (2005)

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While supporting them with folate is important, its also important to ensure that the entire cycle and associated systems are fully supported