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J Physiol 456: 181192, 1992

Many patients report that heartburn symptoms improve within 24 weeks as their body adapts to the medication's effects on digestion

Because the drug is still in trials, its long-term safety profile is not yet fully established

The medication produces changes across multiple dimensions, many of which precede visible weight loss by weeks

The GLP-1 receptor is a G-protein-coupled receptor that has been characterized as a central element of incretin physiology, and its mechanisms of action have been reviewed across cell-based and preclinical model systems

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