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Gastrointestinal effects are the most frequently reported side effects, particularly when starting treatment or increasing the dose

Most providers follow the standard escalation schedule, but some patients need to move up sooner, and a few do well staying at intermediate doses longer

In 2023, the FDA approved a longer-acting IL1 blocking medication called canakinumab (Ilaris) for use in special circumstances

The weight reduction was 2.6 pounds at one year, 8 pounds at three years, and 9 pounds at five years compared with the baseline

Body image improvement follows weight loss but often lags behind

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