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This pattern fits the broader literature suggesting GHRH and GHS co-exposure may be supra-additive an effect generally attributed to the convergence of two distinct receptor pathways (cAMP/PKA for the GHRH receptor and PLC/IP 3 /PKC for GHS-R1a) acting on the same somatotroph cells

doi: 10.3390/biomedicines10051020

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2021 Jul 24;11(8):710

By the late 1970s admissions to hospital and the workload of gastric surgeons had begun to decline as a result of the introduction of H2 receptor agonists, a new class of drugs that block the action of histamine