For example, in animal studies, methylcobalamin significantly prolonged the survival of mice with cancer, while cyanocobalamin was completely ineffective (6)
Real-world dosing and outcomes 6-month persister loss about 12-13% (Hankosky), broad-cohort about -9.8% (Adamidis), telehealth completers near -23% (Duncan)
Benzyl alcohol, at the 0.9% concentration in bacteriostatic water, binds to hydrophobic regions of the peptide and destabilizes its native structure
also found that mucus hypersecretion and muc5AC mRNA were significantly decreased when enzyme-degradation resistant VIP was delivered to the airways of mice with experimentally induced asthma [117]
doi: Seiwerth S, Brcic L, Vuletic L, et al
Both fall within the range that studies show can be effectively delivered intranasally, though the smaller BPC-157 may achieve somewhat higher bioavailability through this route