Across the six published trials, the most common adverse events were headache, mild gastrointestinal effects (diarrhea, flatulence, nausea), nasopharyngitis, fatigue, dizziness, and mild injection-site reactions
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NHS and NICE guidance on weight management focus on sustainable dietary changes, physical activity, and behavioural support rather than supplement timing
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(PubMed) Roswall N, Olsen A, Christensen J, et al
While the effect is real, it is generally modest for most healthy adults and is often exaggerated online