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For many, these are transient and fade as the primary effects begin

Individuals on medications that may stress liver function

In the SURPASS-2 trial, which directly compared tirzepatide to semaglutide 1 mg for type 2 diabetes, nausea rates were 17-22% for tirzepatide across all three dose levels (5 mg, 10 mg, and 15 mg) versus 18% for semaglutide 1 mg

It also prevents free radicals that cause skin pigmentation, blemishes and dark spots

The insulinotropic effects of GIP are dramatically attenuated in T2D patients (52, 53), and this is believed to be a major contributing factor to impaired postprandial insulin secretion in these individuals

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