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Next, the G-BA determines the added benefit of the new weight loss treatment compared to existing therapies for obesity and diabetes

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Thus, the etiology of primary cerebral folate deficiency includes the presence of autoantibodies against the folate receptor (FR1) and mutations in the FOLR1 gene, which encodes the FR1 protein [101]

These patients medical and mental health may be affected in the long term, so all patients should benefit from a multidisciplinary team to assess holistic needs throughout the transition period

Improved insulin response