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Suppressed inflammatory pathways (NLRP1, NLRP3) and oxidative stress ( TABLE 4 Key findings from in vivo studies with APP transgenic mice
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elegans touch neurons expressing high levels of mCherry (via integrated transgene allele bzIs166 [P mec-4 mCherry]), for which previous ultrastructural examination and cell biological characterization provided evidence of high stress and neuronal exopher extrusions 6,7,20
Frozen livers (100 mg) were homogenized in 8x volume of ice-cold 0.6 M perchloric acid solution
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Importantly, combination of metformin and radiation significantly increased cell death, when compared to irradiated vehicle controls, highlighting the potential role for altered cell death in the metformin-mediated radiosensitisation of these cell lines
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