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Importantly, GLP-2R is not expressed on enterocytes

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Why its notable: human trials show that CJC-1295 raises growth hormone (GH) and insulin-like growth factor (IGF-1) levels in controlled settings, when used with appropriate supervision

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Specifically, the ELIXA (lixisenatide) trial studied patients with T2DM who had recent acute coronary syndrome and found that the addition of lixisenatide to conventional therapy did not result in a significant difference in cardiovascular endpoints relative to placebo (Table 1) [56]