next generation glp 1 drugs Next-Gen GLP-1 after Ozempic: Retatrutide to Orforglipron What is the pipeline for

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RSL3 stimulation elevated C3, IL-1, and TNF- levels in mixed glial cultures, while the ferroptosis inhibitor liproxstatin-1 effectively attenuated RSL3-induced neurotoxicity, supporting a role for ferroptotic stress in promoting neurotoxic glial activation

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However, developing inhibitors with higher affinity and specificity is needed due to the high dosage requirement and potential off-target effects

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Here, we generalize the oxidation mechanisms and antioxidant mechanisms of ferroptosis (Fig