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80 AT 2 (/) mice have elevated basal blood pressure and exaggerated pressor responses to exogenous Ang II as compared with wild-type litter mates, which is line with the hypothesis that AT 2 receptors counteract AT 1 receptor-mediated responses

Warshaw EM, Belsito DV, Taylor JS, et al

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Y. Xionget al., Neuroprotective and neurorestorative effects of thymosin 4 treatment following experimental traumatic brain injury, Wiley, Oct. 2012. doi: 10.1111/j.1749-6632.2012.06683.x

This reduced output means skin loses structural support progressively, with wrinkles forming where the weakened matrix can no longer maintain smooth surface topology

However, owing to concerns about its teratogenic and potentially mutagenic effects, its use in TB treatment remains experimental and requires further investigation