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Even though it is possible that CD38 might directly affect the brain, targeting CD38 abrogated disease-associated T H 17 cell immunity, potentially by breaking meningeal to cortical communication via modulation of IL-17A/IL-1 crosstalk (Fig

It also appears to help reduce symptoms of ADHD by influencing serotonin and dopamine levels in the brain, which can support better impulse control, focus, and motivation, particularly when mood and cognitive clarity are affected by stress