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2) a comparative evaluation of pharmacokinetic behaviors and relative bioavailability of ASD via intragastrical administration to rats pretreated with vegetable oil (lipid solubility enhancement), metronidazole (intestinal flora inhibitors), verapamil (P-glycoprotein inhibitors) and urea (penetration enhancers)

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[16] [18] Current clinical guidelines recommend caution and individualized decision-making, given the lack of robust safety data for high-dose injectable vitamin C in pregnancy and lactation

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