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Notably, ISR was not upregulated in muscle, suggesting that the abundance of proteins in the tissue may prevent amino acid levels from falling below the threshold required to induce ISR at day 2 (Extended Data Fig

Xenobiotics are compounds foreign to the bacterium's natural biochemistry, and phase II of their detoxification involves conjugating them to polar, soluble compounds that can be safely excreted from the cell

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There are other things that occur during sleep that are essential, but those are key components of the restorative features of sleep

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