Conversely, repleting GSH levels with precursors of its synthesis such as N-acetyl-cysteine (NAC) or 2-oxothiazolidine-4-carboxylic acid has protective effects
Alternatively, optimizing the binding interface at the protein level by considering the 3D structural features of the target proteins could further improve the kinetic stability of the small molecule-target protein complex (Marchand et al., 2025)
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Safety considerations and contraindications Even natural supplements carry risks, particularly when containing active ingredients at meaningful doses
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