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Intestinal proglucagon cleaves (breaks up) into several different molecules: GLP-1 GLP-2 GRPP Oxyntomodulin The enzyme PCSK1 converts proglucagon to GLP-1 in the central nervous system

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After statistics, we found that proteins increased after the addition of berberine, but after the administration of GLP-1R inhibitor, this trend of berberine was inhibited (Figures 6DG)

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The function of IGF-1 is mainly in tissue growth, development and also cell metabolism, proliferation, cell differentiation and apoptosis (cell death) [5]

One-way ANOVA with Tukeys range test or the KruskalWallis with Dunns multiple comparison test was performed for the one variable with three levels (Carn vs