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When Selectivity Matters Most: The selective action of AOD-9604 is particularly valuable for individuals with insulin resistance, pre-diabetes, or type 2 diabetes who cannot tolerate glucose elevation, those with personal or family history of cancer who wish to avoid IGF-1 elevation, people seeking pure fat loss without muscle gain or other body composition changes, athletes who need fat loss without anabolic effects or hormonal changes that might affect testing, individuals on complex medication regimens where growth hormones effects would require dose adjustments, and those who prefer targeted interventions over systemic hormonal therapy

However, "stronger" also means stronger side effects, with discontinuation rates of 12-18% for retatrutide versus 5-7% for semaglutide