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However, it is unclear whether the peptide has the same anti-inflammatory potential on other dental pulp cell lines (such as fibroblasts and lymphocytes), an in vivo model should be further established to clarify the anti-inflammatory and osteo-/odontoblastic differentiation effect of Pep-B, as well as determine the optimal concentration for in vivo application and improve its stability by modifying the structure or using suitable scaffold materials [64]

NICE-approved weight management interventions include: Dietary and lifestyle modification first-line approach for all patients Orlistat licensed medication for obesity (BMI 30 or 28 with comorbidities) GLP-1 receptor agonists including semaglutide (Wegovy) per NICE TA875 and liraglutide (Saxenda) with restrictions per NICE TA664, for specific patient groups Bariatric surgery for severe obesity meeting strict criteria The NHS emphasises that sustainable weight loss requires behavioural change, nutritional education, and increased physical activity

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