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L-cell populations adapt over weeks and months, not days

In patients with renal dysfunction, refractory hypotension, severe metabolic abnormalities, active seizure, or persistent coma, extracorporeal removal by haemodialysis or haemofiltration may be considered, although there are no controlled trials that demonstrate an improvement in outcome with these measures [8890]

If you are already taking a GLP-1-based medicine and experience any concerning symptoms such as persistent nausea or vomiting, severe or persistent abdominal pain (which may sometimes radiate to the back and could indicate pancreatitis), rapid heart rate, or signs of an allergic reaction you should contact your GP promptly or call 999 / attend an emergency department if symptoms are severe

Our courses are designed to be accessible and easy to understand, even if you have no prior medical training

In the 72-week non-diabetic obesity trial, adults lost -15.0% at 5 mg, -19.5% at 10 mg, and -20.9% at 15 mg. Real-world outcomes vary because dose reached, adherence, and baseline state vary

For long-term treatment, the maintenance dose may be further increased, with some individuals requiring up to 2 mg once weekly