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This raises the possibility that the DA synthesized by - and -cells also locally activates -cell D2R to inhibit SST secretion and thus removes SST-mediated inhibition of insulin and glucagon release 32,91,93,94,95,96,97,98

Among these, compound 2 (Figure 3) demonstrated the strongest inhibitory activity, with an IC 50 value of 6.57 M (94)

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Zang M, Zuc collo A, Hou X, Nagata D, Walsh K, Herscovitz H, Brecher P, Ruderman NB, and Cohen RA: AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells

Kennes B, Dumont I, Brohee D, Hubert C, Neve P