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Both are schedules described in research, not prescriptions

Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance

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Results The results of the preliminary experiments showed increase of rate of reaction with increasing value of pH for non-enzymatic and enzymatic reactions

A similar effect can happen with other treatments such as retinoids, which may cause purging due to the way they affect how skin cells move from the lower layers to the surface (1,2)

The only valid comparison is clinical outcome (weight loss, appetite suppression, blood sugar control), not milligram dose