Insulin-like growth factor 1: common mediator of multiple enterotrophic hormones and growth factors
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GLP-1 receptor agonists like semaglutide (Wegovy) and tirzepatide (Zepbound) have emerged as powerful tools for chronic weight management, but their use in patients with underactive thyroid requires careful medical evaluation
37 The assembly of these complexes seems to be regulated by the oxygen status of hemoglobin and the phosphorylation status of band 3, 37,38 suggesting they play a direct role in the regulation of oxygen-dependent changes in glycolytic and pentose shunt fluxes
However, advancement through Phase 3 trials and approval requires substantial investment
doi:10.1530/eje-11-0616 An Y, Sun Z, Zhang Y, Liu B, Guan Y, Lu M