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There are a handful of small human case reports, but no proper clinical trials

However, it is important to recognise that natural methods produce modest effects compared to pharmaceutical interventions, and no 'natural GLP-1 booster' supplements are licensed in the UK

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It had been suggested, based on studies looking at the expression of 17-Hydroxylase/C17-20-lyase and hydroxysteroid sulfotransferase, that sulfated steroids, such as DHEAS are unlikely to be synthesized de novo within the human hippocampus (186)