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The hepatic bile acid synthesis is tightly regulated by negative feedback mechanisms (199) and by transforming primary into secondary bile acid species, the intestinal microbiota strongly affects bile acid metabolism (200)

These therapies, already well-known in diabetes treatment, are now acknowledged as effective weight-loss tools when combined with behavior modification and health monitoring

Psychiatry 23, 22872301

Acknowledgements We would like to acknowledge the service provided by the Medical Microbiota Center of the First Core Laboratory, National Taiwan University College of Medicine

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