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Personalization is crucial, yet factoring highly complex factors such as genetics, sex, metabolic rate, microbiome composition, socioeconomic status, circadian rhythms, and cultural influences remains challenging

doi: 10.3389/fnmol.2022.1014251 [DOI] [PMC free article] [PubMed] [Google Scholar] 63.Jiang L, Zhang Y, Jing F, Long T, Qin G, Zhang D, et al

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Conversely, inflammatory cytokines promote apoptosis, inhibit chondrocyte proliferation, and induce chondrocytes to release MMP-13, thereby playing a role in matrix degradation