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If body composition or glucose regulation is off, GLP-1 therapy does more for healthspan than any peptide, with phase 3 evidence behind it (14.9% weight loss in STEP 1, Wilding 2021 NEJM
Nat Commun 14(1):4193 Hou B, Liu M, Chen Y et al (2022) Cpd-42 protects against calcium oxalate nephrocalcinosis-induced renal injury and inflammation by targeting RIPK3-mediated necroptosis
If tests show deficiency, replacement is justified and often rapidly helpful
Hippocampal BICD2 knockout in CUMS mouse models of depression shows an antidepressant effect, which may be mediated by increased BDNF expression 133