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Retatrutide is Lilly's step-change beyond tirzepatide, the molecule behind Mounjaro and Zepbound, activating three hormone receptors (GIP, GLP-1, and glucagon) rather than two

Finally, with renewed focus on supply chain integrity, both 503Bs and 503As must maintain robust documentation to demonstrate compliance with DSCSA requirements, prescription validity, and non-duplication with FDA-approved therapies

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We reviewed publications for clinical relevance