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Unlike vitamin B12 deficiency, which produces well-recognised neurological and haematological problems, hypercobalaminaemia (elevated B12) is typically asymptomatic

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High doses might also possibly interfere with levels of other vitamins, enzymes and minerals, which is always a potential problem when taking any nutrient in very large quantities

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Characterization of antibodies against receptor activity-modifying protein 1 (RAMP1): a cautionary tale