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People taking other diabetes medications or eating much less than usual while taking semaglutide should be especially cautious because they are at an increased risk of hypoglycemia

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15, 2025 Tripling the standard dose of semaglutide, a popular drug prescribed to treat obesity, led to significantly greater weight loss and associated metabolic benefits without increased risk of serious side effects, a multicenter clinical trial led by a UT Southwestern Medical Center researcher shows

and 1 with 100 macrovascular complications, including ischemic heart disease, myocardial infarction (first and subsequent), stroke (first and subsequent) and congestive heart failure (Figure 1)