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Elevated homocysteine levels have been linked to heart disease, stroke and endocrine disorders like hyperinsulinemia

The natural history of hyperuricemia among asymptomatic relatives of patients with gout

The liver metabolizes it using a substance called glutathione

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This process is driven by disrupted GSH homeostasis, resulting from diminished GSH synthesis and impaired activity of two critical antioxidant systems: (1) the cystine/glutamate antiporter xCT, which imports cystine to fuel GSH production and (2) GPX4, which utilizes GSH to convert lipid peroxides into less toxic lipid alcohols (Stockwell et al., 2017