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Research efforts are also focused on understanding how variations in experimental design, concentration, and molecular stability may affect peptide behavior across different in vitro systems

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In low-grade dysplasia (LGD) there is cytological atypia up to the mucosal surface (Figure 2), nuclear atypia with hyperchromatism and pleomorphism, increased mitosis, and crowding of glands with decreased intervening lamina propria, but nuclear polarity is preserved

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