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How the MHRA Assesses Borderline Products The MHRA can consider whether a product is presented as preventing or treating disease, or whether it is intended to restore, correct or modify a physiological function through pharmacological, immunological or metabolic action

Berberine is derived naturally from multiple plants and has been scientifically shown to activate the enzyme known as AMP-activated protein kinase, or AMPK, which promotes metabolism regulation and the oxidation of fat

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In the last decades, it has been shown that aminochrome, the product of dopamine autoxidation, can induce most of these changes and that the rate of some of them is pH dependent (Garca-Moreno et al., substantia nigra are especially susceptible to dopamine neurotoxicity compared to the more resistant dopaminergic neurons in the ventral tegmental area