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Whilst this study primarily focused on metformin-mediated effects in tumour cells, increasing evidence implicates a role for metformin in the modulation of immune cells, with metformin demonstrated to modulate macrophage polarisation (71) and the infiltration and function of T-cells (72, 73)

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But if it breaks and you get a blood clot that is big enough in the acute moment to block the whole artery, thats what usually causes most heart attacks

The intent here is to have some therapeutic effects, Aziz said

You don't want to be starving, but you also don't want to feel overly full