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In contrast, OTC products are one-size-fits-all and may lack potency or safety for persistent melasma

In fact, similar to A-targeted immunotherapy, most of the ATAs are not able to cross an intact BBB (Janowicz et al., 2019), and led to toxic side effects, such as vascular edema, encephalomyelitis associated with neurological deficits, axonal damage and inflammation (Rosenmann et al., 2006