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A unimolecular AMYR/CTR/GLP-1R multi-agonist peptide, amycretin has been developed for weekly injection and as a once-daily tablet

GSH positively enhances the expression of CYP27B1 , leading to the conversion of 25(OH)VD to 1,25(OH) 2 VD [44,47]

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Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation

Additionally, insulin-stimulated glycogen synthesis occurs through the PI3K/AKT signaling cascade, promoting glycogenesis and transiently buffering hepatic glucose overload [100, 101]

Achieving specificity is the biggest challenge in the development of Nrf2 inhibitors