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It is acylated at the N-terminus with a C20 fatty diacid linked via a -glutamic acid spacer, and carries an intramolecular disulfide bond between Cys3 and Cys8 structural modifications that extend its half-life and reduce fibril formation relative to native amylin

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While these results may suggest a more frequently displaced window of implantation in the endometrium of older women undergoing IVF with fresh embryo transfer, this study does not separate the contribution of the embryo (which is more likely to be aneuploid in older subjects) from the contribution of the endometrium even though synchrony is a composite of the two

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This enhances appetite and promotes the reward-driven intake of high-fat diets