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HIV is transmitted through body fluids such as blood, semen (cum), pre-seminal fluid (pre-cum), vaginal fluids, rectal fluids and breast milk from a person who has HIV

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Trials of combination NRT were used to inform this estimate because: (1) randomized trials of a high-dose nicotine patch are not available to inform the projected treatment size, and (2) similar to nicotine patch, combination NRT also allows upward titration to reach satiety