This triple mechanism distinguishes it from existing agents such as semaglutide (a GLP-1 agonist) or tirzepatide (a dual GIP/GLP-1 agonist)
Notably, PTC cell lines with relatively low basal GPX4 expression, such as MDA-T32 and MDA T-68 cells, had a lower LC 50 compared to K1 cells with high GPX4 expression
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Clinical trial meta-analyses show a statistically significant association between semaglutide (and GLP-1 agonists broadly) and increased DVT risk