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Proliferation new tissue is built: fibroblasts lay down fresh collagen and extracellular matrix, and new blood vessels form to supply it

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The bigger question is whether it does enough for the cost, and what realistic expectations are

The perturbation of cellular glutathione homeostasis was achieved by exposing hepatocytes to H 2 O 2 , which is a well-established method of inducing intracellular glutathione imbalance

For instance, it remains unclear how ferroptosis in neutrophils [e.g., GPX4 deficiency-induced iron release (216)] directly modulates T/B-cell differentiation or macrophage activation, or whether DAMPs released by ferroptotic immune cells propagate ferroptosis in renal parenchymal cells (e.g., tubular epithelial cells)